Practical Stereology Applications for the Pathologist.
Vet Pathol
; 54(3): 358-368, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-28438109
ABSTRACT
Qualitative histopathology is the gold standard for routine examination of morphological tissue changes in the regulatory or academic environment. The human eye is exceptional for pattern recognition but often cannot detect small changes in quantity. In cases where detection of subtle quantitative changes is critical, more sensitive methods are required. Two-dimensional histomorphometry can provide additional quantitative information and is quite useful in many cases. However, the provided data may not be referent to the entire tissue and, as such, it makes several assumptions, which are sources of bias. In contrast, stereology is design based rather than assumption based and uses stringent sampling methods to obtain accurate and precise 3-dimensional information using geometrical and statistical principles. Recent advances in technology have made stereology more approachable and practical for the pathologist in both regulatory and academic environments. This review introduces pathologists to the basic principles of stereology and walks the reader through some real-world examples for the application of these principles in the workplace.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Patologia Veterinária
/
Imageamento Tridimensional
Tipo de estudo:
Qualitative_research
Limite:
Animals
Idioma:
En
Revista:
Vet Pathol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos