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The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma.
Miyahara, Hiroaki; Yadavilli, Sridevi; Natsumeda, Manabu; Rubens, Jeffrey A; Rodgers, Louis; Kambhampati, Madhuri; Taylor, Isabella C; Kaur, Harpreet; Asnaghi, Laura; Eberhart, Charles G; Warren, Katherine E; Nazarian, Javad; Raabe, Eric H.
Afiliação
  • Miyahara H; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Yadavilli S; Research Center for Genetic Medicine, Children's National Health System, Washington, District of Columbia 20010, USA.
  • Natsumeda M; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Rubens JA; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Rodgers L; National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
  • Kambhampati M; Research Center for Genetic Medicine, Children's National Health System, Washington, District of Columbia 20010, USA.
  • Taylor IC; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kaur H; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Asnaghi L; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Eberhart CG; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Warren KE; National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA.
  • Nazarian J; Research Center for Genetic Medicine, Children's National Health System, Washington, District of Columbia 20010, USA; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia 20052, USA.
  • Raabe EH; Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: eraabe2@jhmi.edu.
Cancer Lett ; 400: 110-116, 2017 08 01.
Article em En | MEDLINE | ID: mdl-28450157
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Radiossensibilizantes / Tolerância a Radiação / Benzoxazóis / Neoplasias do Tronco Encefálico / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Quimiorradioterapia / Glioma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Radiossensibilizantes / Tolerância a Radiação / Benzoxazóis / Neoplasias do Tronco Encefálico / Inibidores de Proteínas Quinases / Serina-Treonina Quinases TOR / Quimiorradioterapia / Glioma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos