Proteasomal and Autophagic Degradation Systems.
Annu Rev Biochem
; 86: 193-224, 2017 06 20.
Article
em En
| MEDLINE
| ID: mdl-28460188
ABSTRACT
Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis. As such, they provide protection against age-associated changes and a plethora of human diseases. Ubiquitination is utilized as a degradation signal by both systems, albeit in different ways, to mark cargoes for proteasomal and lysosomal degradation. Both systems intersect and communicate at multiple points to coordinate their actions in proteostasis and organelle homeostasis. This review summarizes molecular details of how proteasome and autophagy pathways are functionally interconnected in cells and indicates common principles and nodes of communication that can be therapeutically exploited.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Ubiquitina
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Complexo de Endopeptidases do Proteassoma
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Fator 2 Relacionado a NF-E2
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Proteína 1 Associada a ECH Semelhante a Kelch
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Proteína Sequestossoma-1
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2017
Tipo de documento:
Article