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Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine.
Greenwood, Brian; Dicko, Alassane; Sagara, Issaka; Zongo, Issaka; Tinto, Halidou; Cairns, Matthew; Kuepfer, Irene; Milligan, Paul; Ouedraogo, Jean-Bosco; Doumbo, Ogobara; Chandramohan, Daniel.
Afiliação
  • Greenwood B; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK. brian.greenwood@lshtm.ac.uk.
  • Dicko A; Malaria Research and Training Centre, University of Sciences Techniques and Technologies, Bamako, Mali.
  • Sagara I; Malaria Research and Training Centre, University of Sciences Techniques and Technologies, Bamako, Mali.
  • Zongo I; Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
  • Tinto H; Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
  • Cairns M; Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Kuepfer I; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
  • Milligan P; Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Ouedraogo JB; Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
  • Doumbo O; Malaria Research and Training Centre, University of Sciences Techniques and Technologies, Bamako, Mali.
  • Chandramohan D; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St., London, WC1E 7HT, UK.
Malar J ; 16(1): 182, 2017 05 02.
Article em En | MEDLINE | ID: mdl-28464937
In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal. Seasonal malaria chemoprevention (SMC), which involves administration of a full course of malaria treatment to young children at monthly intervals during the high transmission season, is proving to be an effective malaria control measure in these areas. However, SMC does not provide complete protection and it is demanding to deliver for both families and healthcare givers. Furthermore, there is a risk of the emergence in the future of resistance to the drugs, sulfadoxine-pyrimethamine and amodiaquine, that are currently being used for SMC. Substantial progress has been made in the development of malaria vaccines during the past decade and one malaria vaccine, RTS,S/AS01, has received a positive opinion from the European Medicines Authority and will soon be deployed in large-scale, pilot implementation projects in sub-Saharan Africa. A characteristic feature of this vaccine, and potentially of some of the other malaria vaccines under development, is that they provide a high level of efficacy during the period immediately after vaccination, but that this wanes rapidly, perhaps because it is difficult to develop effective immunological memory to malaria antigens in subjects exposed previously to malaria infection. A potentially effective way of using malaria vaccines with high initial efficacy but which provide only a short period of protection could be annual, mass vaccination campaigns shortly before each malaria transmission season in areas where malaria transmission is confined largely to a few months of the year.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estações do Ano / Vacinas Sintéticas / Vacinação / Vacinas Antimaláricas / Malária País/Região como assunto: Africa Idioma: En Revista: Malar J Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estações do Ano / Vacinas Sintéticas / Vacinação / Vacinas Antimaláricas / Malária País/Região como assunto: Africa Idioma: En Revista: Malar J Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2017 Tipo de documento: Article