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Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
Robbiani, Davide F; Bozzacco, Leonia; Keeffe, Jennifer R; Khouri, Ricardo; Olsen, Priscilla C; Gazumyan, Anna; Schaefer-Babajew, Dennis; Avila-Rios, Santiago; Nogueira, Lilian; Patel, Roshni; Azzopardi, Stephanie A; Uhl, Lion F K; Saeed, Mohsan; Sevilla-Reyes, Edgar E; Agudelo, Marianna; Yao, Kai-Hui; Golijanin, Jovana; Gristick, Harry B; Lee, Yu E; Hurley, Arlene; Caskey, Marina; Pai, Joy; Oliveira, Thiago; Wunder, Elsio A; Sacramento, Gielson; Nery, Nivison; Orge, Cibele; Costa, Federico; Reis, Mitermayer G; Thomas, Neena M; Eisenreich, Thomas; Weinberger, Daniel M; de Almeida, Antonio R P; West, Anthony P; Rice, Charles M; Bjorkman, Pamela J; Reyes-Teran, Gustavo; Ko, Albert I; MacDonald, Margaret R; Nussenzweig, Michel C.
Afiliação
  • Robbiani DF; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. Electronic address: drobbiani@rockefeller.edu.
  • Bozzacco L; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Khouri R; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil.
  • Olsen PC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Avila-Rios S; National Institute of Respiratory Diseases, Mexico City CP 14080, Mexico.
  • Nogueira L; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Patel R; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Azzopardi SA; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Uhl LFK; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Saeed M; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Sevilla-Reyes EE; National Institute of Respiratory Diseases, Mexico City CP 14080, Mexico.
  • Agudelo M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Yao KH; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Golijanin J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Lee YE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Hurley A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Pai J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Oliveira T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Wunder EA; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA.
  • Sacramento G; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil.
  • Nery N; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil.
  • Orge C; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil.
  • Costa F; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA; Faculdade de Medicina da Bahia and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador,
  • Reis MG; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA; Faculdade de Medicina da Bahia and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador,
  • Thomas NM; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Eisenreich T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Weinberger DM; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA.
  • de Almeida ARP; Faculdade de Medicina da Bahia and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia CEP 40296-710, Brazil.
  • West AP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Reyes-Teran G; National Institute of Respiratory Diseases, Mexico City CP 14080, Mexico.
  • Ko AI; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia CEP 40296-710, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA.
  • MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address: macdonm@rockefeller.edu.
  • Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: nussen@rockefeller.edu.
Cell ; 169(4): 597-609.e11, 2017 May 04.
Article em En | MEDLINE | ID: mdl-28475892
Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil and Mexico for ZIKV envelope domain III (ZEDIII) binding and neutralization. We find that serologic reactivity to dengue 1 virus (DENV1) EDIII before ZIKV exposure is associated with increased ZIKV neutralizing titers after exposure. Antibody cloning shows that donors with high ZIKV neutralizing antibody titers have expanded clones of memory B cells that express the same immunoglobulin VH3-23/VK1-5 genes. These recurring antibodies cross-react with DENV1, but not other flaviviruses, neutralize both DENV1 and ZIKV, and protect mice against ZIKV challenge. Structural analyses reveal the mechanism of recognition of the ZEDIII lateral ridge by VH3-23/VK1-5 antibodies. Serologic testing shows that antibodies to this region correlate with serum neutralizing activity to ZIKV. Thus, high neutralizing responses to ZIKV are associated with pre-existing reactivity to DENV1 in humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / Infecção por Zika virus / Anticorpos Antivirais Limite: Animals / Female / Humans / Male País/Região como assunto: America do sul / Brasil / Mexico Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / Infecção por Zika virus / Anticorpos Antivirais Limite: Animals / Female / Humans / Male País/Região como assunto: America do sul / Brasil / Mexico Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article