Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations.

Cantrill, Carina; Houston, J Brian

Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations.

Cantrill, Carina; Houston, J Brian.

Afiliação

Cantrill C; Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Biology, Medicine and Health Sciences, University of Manchester, UK.
Houston JB; Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Biology, Medicine and Health Sciences, University of Manchester, UK. Electronic address: brian.houston@manchester.ac.uk.

J Pharm Sci ; 106(9): 2815-2825, 2017 09.

Article em En | MEDLINE | ID: mdl-28478131

Assuntos

Eliminação Hepatobiliar; Hepatócitos/metabolismo; Preparações Farmacêuticas/metabolismo; Animais; Transporte Biológico; Células Cultivadas; Humanos; Fígado/metabolismo; Masculino; Proteínas de Membrana Transportadoras/metabolismo; Ratos Sprague-Dawley

Palavras-chave

hepatic clearance; hepatic transport; hepatobiliary disposition; hepatocytes; transporters

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Hepatócitos / Eliminação Hepatobiliar Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Pharm Sci Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

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