Your browser doesn't support javascript.
loading
Erythrocyte membrane nanoparticles improve the intestinal absorption of paclitaxel.
Jiang, Xing; Wang, Kaikai; Zhou, Zaigang; Zhang, Yifan; Sha, Huizi; Xu, Qiuping; Wu, Jie; Wang, Juan; Wu, Jinhui; Hu, Yiqiao; Liu, Baorui.
Afiliação
  • Jiang X; The Comprehensive Cancer Center of Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China; College of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, China; The Comprehensive Cancer Center of D
  • Wang K; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210028, China.
  • Zhou Z; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.
  • Zhang Y; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.
  • Sha H; The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China.
  • Xu Q; The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China.
  • Wu J; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.
  • Wang J; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China.
  • Wu J; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address: wuj@nju.edu.cn.
  • Hu Y; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address: huyiqiao@nju.edu.cn.
  • Liu B; The Comprehensive Cancer Center of Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China; The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Inst
Biochem Biophys Res Commun ; 488(2): 322-328, 2017 06 24.
Article em En | MEDLINE | ID: mdl-28495530
Paclitaxel (PTX) is a cytotoxic chemotherapy drug with encouraging activity in human malignancies. However, free PTX has a very low oral bioavailability due to its low aqueous solubility and the gastrointestinal drug barrier. In order to overcome this obstacle, we have designed erythrocyte membrane nanoparticles (EMNP) using sonication method. The permeability of PTX by EMNP was 3.5-fold (Papp = 0.425 nm/s) and 16.2-fold (Papp = 394.1 nm/s) higher than free PTX in MDCK-MDR1 cell monolayers and intestinal mucosal tissue, respectively. The in vivo pharmacokinetics indicated that the AUC0-t (µg/mL·h) and Cmax (µg/mL) of EMNP were 14.2-fold and 6.0-fold higher than that of free PTX, respectively. In summary, the EMNP appears to be a promising nanoformulation to enhance the oral bioavailability of insoluble and poorly permeable drugs.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paclitaxel / Membrana Eritrocítica / Nanopartículas / Absorção Intestinal / Antineoplásicos Fitogênicos Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paclitaxel / Membrana Eritrocítica / Nanopartículas / Absorção Intestinal / Antineoplásicos Fitogênicos Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2017 Tipo de documento: Article