The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

Hong, Weimin Conrad; Yano, Hideaki; Hiranita, Takato; Chin, Frederick T; McCurdy, Christopher R; Su, Tsung-Ping; Amara, Susan G; Katz, Jonathan L

Hong, Weimin Conrad; Yano, Hideaki; Hiranita, Takato; Chin, Frederick T; McCurdy, Christopher R; Su, Tsung-Ping; Amara, Susan G; Katz, Jonathan L.

Afiliação

Hong WC; From the Department of Pharmaceutical Sciences, Butler University, Indianapolis, Indiana 46208, chong@butler.edu.
Yano H; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Hiranita T; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Chin FT; Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, California 94305.
McCurdy CR; the Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, and.
Su TP; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Amara SG; the Laboratory of Molecular and Cellular Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20892.
Katz JL; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.

J Biol Chem ; 292(27): 11250-11261, 2017 07 07.

Article em En | MEDLINE | ID: mdl-28495886

Assuntos

Comportamento Animal/efeitos dos fármacos; Cocaína; Corpo Estriado; Proteínas da Membrana Plasmática de Transporte de Dopamina; Receptores sigma; Sinaptossomos; Animais; Cocaína/química; Cocaína/farmacocinética; Cocaína/farmacologia; Corpo Estriado/química; Corpo Estriado/metabolismo; Proteínas da Membrana Plasmática de Transporte de Dopamina/metabolismo; Guanidinas/química; Guanidinas/farmacocinética; Guanidinas/farmacologia; Masculino; Morfolinas/química; Morfolinas/farmacocinética; Morfolinas/farmacologia; Conformação Proteica; Ratos; Ratos Sprague-Dawley; Receptores sigma/química; Receptores sigma/metabolismo; Sinaptossomos/química; Sinaptossomos/metabolismo

Palavras-chave

Sigma-1 receptor; cocaine binding; cocaine self-administration; conformational change; cysteine accessibility; dopamine transporter; ligand-binding protein; oligomerization; sigma receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinaptossomos / Comportamento Animal / Receptores sigma / Cocaína / Corpo Estriado / Proteínas da Membrana Plasmática de Transporte de Dopamina Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article

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