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Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies.
Latimer, Caitlin S; Keene, C Dirk; Flanagan, Margaret E; Hemmy, Laura S; Lim, Kelvin O; White, Lon R; Montine, Kathleen S; Montine, Thomas J.
Afiliação
  • Latimer CS; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • Keene CD; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • Flanagan ME; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • Hemmy LS; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • Lim KO; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • White LR; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • Montine KS; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
  • Montine TJ; From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Cli
J Neuropathol Exp Neurol ; 76(6): 458-466, 2017 Jun 01.
Article em En | MEDLINE | ID: mdl-28499012
ABSTRACT
Two population-based studies key to advancing knowledge of brain aging are the Honolulu-Asia Aging Study (HAAS) and the Nun Study. Harmonization of their neuropathologic data allows cross comparison, with findings common to both studies likely generalizable, while distinct observations may point to aging brain changes that are dependent on sex, ethnicity, environment, or lifestyle factors. Here, we expanded the neuropathologic evaluation of these 2 studies using revised NIA-Alzheimer's Association guidelines and compared directly the neuropathologic features of resistance and apparent cognitive resilience. There were significant differences in prevalence of Alzheimer disease neuropathologic change, small vessel vascular brain injury, and Lewy body disease between these 2 studies, suggesting that sex, ethnicity, and lifestyle factors may significantly influence resistance to developing brain injury with age. In contrast, hippocampal sclerosis prevalence was very similar, but skewed to poorer cognitive performance, suggesting that hippocampal sclerosis could act sequentially with other diseases to impair cognitive function. Strikingly, despite these observed differences, the proportion of individuals resistant to all 4 diseases of brain or displaying apparent cognitive resilience was virtually identical between HAAS and Nun Study participants. Future in vivo validation of these results awaits comprehensive biomarkers of these 4 brain diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Cognição / Resiliência Psicológica / Doença de Alzheimer / Freiras Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Neuropathol Exp Neurol Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Cognição / Resiliência Psicológica / Doença de Alzheimer / Freiras Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: J Neuropathol Exp Neurol Ano de publicação: 2017 Tipo de documento: Article