The influence of electroshock on adrenoceptor function in rat brain cerebral cortex: selectivity for the alpha-adrenoceptor site.
Eur J Pharmacol
; 156(1): 143-7, 1988 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-2850206
ABSTRACT
The present study was undertaken to examine the effect of electroshock on adrenoceptor-mediated cAMP and inositol phosphate accumulation in rat brain cerebral cortical slices. Under the conditions of these experiments, isoproterenol-induced cAMP accumulation was unaltered by electroshock, although there was a significant reduction in the norepinephrine- and isoproterenol + 6-fluoronorepinephrine-stimulated responses. No change in alpha-adrenoceptor-mediated inositol phosphate accumulation was noted. The results indicate that electroshock selectively modifies an alpha-adrenoceptor system in brain that differs from that associated with inositol phosphate accumulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Receptores Adrenérgicos alfa
/
Eletrochoque
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Polônia