Neural circuits for long-term water-reward memory processing in thirsty Drosophila.
Nat Commun
; 8: 15230, 2017 05 15.
Article
em En
| MEDLINE
| ID: mdl-28504254
ABSTRACT
The intake of water is important for the survival of all animals and drinking water can be used as a reward in thirsty animals. Here we found that thirsty Drosophila melanogaster can associate drinking water with an odour to form a protein-synthesis-dependent water-reward long-term memory (LTM). Furthermore, we found that the reinforcement of LTM requires water-responsive dopaminergic neurons projecting to the restricted region of mushroom body (MB) ß' lobe, which are different from the neurons required for the reinforcement of learning and short-term memory (STM). Synaptic output from α'ß' neurons is required for consolidation, whereas the output from γ and αß neurons is required for the retrieval of LTM. Finally, two types of MB efferent neurons retrieve LTM from γ and αß neurons by releasing glutamate and acetylcholine, respectively. Our results therefore cast light on the cellular and molecular mechanisms responsible for processing water-reward LTM in Drosophila.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recompensa
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Ingestão de Líquidos
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Drosophila melanogaster
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Memória de Longo Prazo
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Rede Nervosa
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Taiwan