Substantial Impairment of Voriconazole Clearance by High-Dose Meropenem in a Patient With Renal Failure.

Mahmoudi, Mazyar; Brenner, Thorsten; Hatiboglu, Gencay; Burhenne, Jürgen; Weiss, Johanna; Weigand, Markus A; Haefeli, Walter E

Mahmoudi, Mazyar; Brenner, Thorsten; Hatiboglu, Gencay; Burhenne, Jürgen; Weiss, Johanna; Weigand, Markus A; Haefeli, Walter E.

Afiliação

Mahmoudi M; Departments of Clinical Pharmacology and Pharmacoepidemiology.
Brenner T; Anesthesiology.
Hatiboglu G; Urology, Heidelberg University Hospital, Germany.
Burhenne J; Departments of Clinical Pharmacology and Pharmacoepidemiology.
Weiss J; Departments of Clinical Pharmacology and Pharmacoepidemiology.
Weigand MA; Anesthesiology.
Haefeli WE; Departments of Clinical Pharmacology and Pharmacoepidemiology.

Clin Infect Dis ; 65(6): 1033-1036, 2017 Sep 15.

Article em En | MEDLINE | ID: mdl-28505263

RESUMO

A critically ill patient with multiple postoperative infections repeatedly required profound voriconazole dose reductions whenever high-dose meropenem was added. Subsequent in vitro assessment confirmed inhibition of cytochrome P450 (CYP) 2C19 and CYP3A4 by meropenem, suggesting that during meropenem treatment, narrow therapeutic index drugs metabolized by these CYPs require close monitoring.

Assuntos

Inibidores do Citocromo P-450 CYP2C19/farmacologia; Inibidores do Citocromo P-450 CYP3A/farmacologia; Tienamicinas/farmacologia; Voriconazol/farmacocinética; Idoso; Inibidores do Citocromo P-450 CYP2C19/administração & dosagem; Inibidores do Citocromo P-450 CYP3A/administração & dosagem; Interações Medicamentosas; Monitoramento de Medicamentos; Humanos; Masculino; Meropeném; Insuficiência Renal/fisiopatologia; Tienamicinas/administração & dosagem; Voriconazol/administração & dosagem

Palavras-chave

critically ill; cytochrome P450; drug interaction; meropenem; voriconazole

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tienamicinas / Voriconazol / Inibidores do Citocromo P-450 CYP2C19 / Inibidores do Citocromo P-450 CYP3A Limite: Aged / Humans / Male Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article

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