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Roles of Retinoic Acid in Germ Cell Differentiation.
Teletin, Marius; Vernet, Nadège; Ghyselinck, Norbert B; Mark, Manuel.
Afiliação
  • Teletin M; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique (CNRS), Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université de Strasbourg (UNISTRA), Strasbourg, France; Hôp
  • Vernet N; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique (CNRS), Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université de Strasbourg (UNISTRA), Strasbourg, France.
  • Ghyselinck NB; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique (CNRS), Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université de Strasbourg (UNISTRA), Strasbourg, France.
  • Mark M; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France; Centre National de la Recherche Scientifique (CNRS), Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université de Strasbourg (UNISTRA), Strasbourg, France; Hôp
Curr Top Dev Biol ; 125: 191-225, 2017.
Article em En | MEDLINE | ID: mdl-28527572
ABSTRACT
The modalities of gametogenesis differ markedly between sexes. Female are born with a definitive reserve of oocytes whose size is crucial to ensure fertility. Male fertility, in contrast, relies on a tightly regulated balance between germ cell self-renewal and differentiation, which operates throughout life, according to recurring spatial and temporal patterns. Genetic and pharmacological studies conducted in the mouse and discussed in this review have revealed that all-trans retinoic acid and its nuclear receptors are major players of gametogenesis and are instrumental to fertility in both sexes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óvulo / Espermatozoides / Tretinoína / Gametogênese Limite: Animals / Female / Humans / Male Idioma: En Revista: Curr Top Dev Biol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óvulo / Espermatozoides / Tretinoína / Gametogênese Limite: Animals / Female / Humans / Male Idioma: En Revista: Curr Top Dev Biol Ano de publicação: 2017 Tipo de documento: Article