M2BPGi as a potential diagnostic tool of cirrhosis in Chinese patients with Hepatitis B virus infection.
J Clin Lab Anal
; 32(2)2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-28544156
ABSTRACT
BACKGROUND:
M2BPGi is a novel serum glycobiomarker of liver fibrosis. In this study, we aimed to evaluate the efficacy of M2BPGi for predicting liver fibrosis and disease progression in Chinese hepatitis B virus (HBV) infected patients.METHODS:
We enrolled 228 HBV infected patients with different status of liver fibrosis diagnosed using FibroScan. We analyzed the diagnostic accuracy of M2BPGi, and compared it with AST-to-platelet ratio (APRI), FIB-4 index, AST to ALT ratio (AAR), and RDW to platelet ratio (RPR). We performed receiver operating characteristics curve (ROC) to evaluate the diagnostic performance of M2BPGi for significant fibrosis and cirrhosis.RESULTS:
Median M2BPGi values in each fibrosis stage were 0.88 cut-off index (COI) in F0-1, 1.165 in F2-3, and 1.92 in F4 (P<.01), respectively. For F≥2, the sensitivity, specificity, accuracy of M2BPGi were 72.28%, 73.23%, 66.67%, while 55.07%, 93.71%, 82.02% for F≥4. For predicting significant fibrosis (≥F2), M2BPGi showed comparable performance to FIB4 index (P<.01), APRI (P<.01) and RPR (P<.01) with area under the ROC curve (AUC) of 0.788. M2BPGi was superior to other surrogate markers for diagnosing cirrhosis (F4) with the highest AUC of 0.811 (P<.01).CONCLUSIONS:
M2BPGi levels increased with the progression of liver fibrosis in HBV infected patients. M2BPGi can be served as a potential glycobiomarker to assess the stage of liver fibrosis, especially for the diagnosis of cirrhosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Hepatite B
/
Cirrose Hepática
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Clin Lab Anal
Assunto da revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China