Functional impairment in RHOT1/Miro1 degradation and mitophagy is a shared feature in familial and sporadic Parkinson disease.
Autophagy
; 13(8): 1259-1261, 2017 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-28598233
ABSTRACT
Mitophagy is a conserved and highly regulated process of selective degradation crucial in maintaining normal cellular physiology. Genetic defects and cellular aberrations affecting mitophagy have been associated with the development of Parkinson disease. In their recently published article (highlighted in a punctum in this issue of the journal) Hsieh et al. present a putative mitophagy marker, which serves as a mechanistic link between sporadic and familial Parkinson disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Proteínas Mitocondriais
/
Mitofagia
Limite:
Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos