The relative utilities of genome-wide, gene panel, and individual gene sequencing in clinical practice.
Blood
; 130(4): 433-439, 2017 07 27.
Article
em En
| MEDLINE
| ID: mdl-28600338
ABSTRACT
Advances in technology that have transpired over the past 2 decades have enabled the analysis of cancer samples for genomic alterations to understand their biologic function and to translate that knowledge into clinical practice. With the power to analyze entire genomes in a clinically relevant time frame and with manageable costs comes the question of whether we ought to and when. This review focuses on the relative merits of 3 approaches to molecular diagnostics in hematologic malignancies indication-specific single gene assays, gene panel assays that test for genes selected for their roles in cancer, and genome-wide assays that broadly analyze the tumor exomes or genomes. After addressing these in general terms, we review specific use cases in myeloid and lymphoid malignancies to highlight the utility of single gene testing and/or larger panels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
/
Estudo de Associação Genômica Ampla
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Sequenciamento de Nucleotídeos em Larga Escala
/
Exoma
Limite:
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Marrocos