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Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin.
Escobar, Beatriz; Montenegro, Iván; Villena, Joan; Werner, Enrique; Godoy, Patricio; Olguín, Yusser; Madrid, Alejandro.
Afiliação
  • Escobar B; Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile. escobarbeatriz25@gmail.com.
  • Montenegro I; Escuela de Obstetricia y Puericultura, Facultad de medicina, Campus de la Salud, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile. ivan.montenegro@uv.cl.
  • Villena J; Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda Nº 2664, Valparaíso 2340000, Chile. ivan.montenegro@uv.cl.
  • Werner E; Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda Nº 2664, Valparaíso 2340000, Chile. juan.villena@uv.cl.
  • Godoy P; Departamento De Ciencias Básicas, Campus Fernando May Universidad del Biobío. Avda. Andrés Bello s/n casilla 447, Chillán 3780000, Chile. ewerner@ubiobio.cl.
  • Olguín Y; Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Los Laureles s/n, Isla Teja, Valdivia 5090000, Chile. patricio.godoy@uach.cl.
  • Madrid A; Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile. yusser.olguin@unab.cl.
Molecules ; 22(6)2017 Jun 10.
Article em En | MEDLINE | ID: mdl-28604594
An efficient synthesis of a series of 4'-oxyalkyl-isocordoin analogues (2-8) is reported for the first time. Their structures were confirmed by ¹H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4'-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esporos Fúngicos / Catecóis / Micélio / Saprolegnia Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esporos Fúngicos / Catecóis / Micélio / Saprolegnia Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile