Exploiting natural killer group 2D receptors for CAR T-cell therapy.
Future Oncol
; 13(18): 1593-1605, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28613086
ABSTRACT
Chimeric antigen receptors (CARs) are genetically engineered proteins that combine an extracellular antigen-specific recognition domain with one or several intracellular T-cell signaling domains. When expressed in T cells, these CARs specifically trigger T-cell activation upon antigen recognition. While the clinical proof of principle of CAR T-cell therapy has been established in hematological cancers, CAR T cells are only at the early stages of being explored to tackle solid cancers. This special report discusses the concept of exploiting natural killer cell receptors as an approach that could broaden the specificity of CAR T cells and potentially enhance the efficacy of this therapy against solid tumors. New data demonstrating feasibility of this approach in humans and supporting the ongoing clinical trial are also presented.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Imunoterapia Adotiva
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Subfamília K de Receptores Semelhantes a Lectina de Células NK
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Antígenos de Neoplasias
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Bélgica