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Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.
Yan, Yuetian; Wei, Hui; Jusuf, Sutjano; Krystek, Stanley R; Chen, Jie; Chen, Guodong; Ludwig, Richard T; Tao, Li; Das, Tapan K.
Afiliação
  • Yan Y; Biologics Development, Bristol-Myers Squibb, Pennington, New Jersey 08534; Department of Chemistry, Washington University, Saint Louis, Missouri 63130.
  • Wei H; Biologics Development, Bristol-Myers Squibb, Pennington, New Jersey 08534. Electronic address: hui.wei@bms.com.
  • Jusuf S; Molecular Discovery Technologies, Bristol-Myers Squibb, Princeton, New Jersey 08543.
  • Krystek SR; Molecular Discovery Technologies, Bristol-Myers Squibb, Princeton, New Jersey 08543.
  • Chen J; Process Developent, Bristol-Myers Squibb, Devens, Massachusetts 01434.
  • Chen G; Bioanalytical and Discovery Analytical Science, Bristol-Myers Squibb, Princeton, New Jersey 08543.
  • Ludwig RT; Biologics Development, Bristol-Myers Squibb, Pennington, New Jersey 08534.
  • Tao L; Biologics Development, Bristol-Myers Squibb, Pennington, New Jersey 08534.
  • Das TK; Biologics Development, Bristol-Myers Squibb, Pennington, New Jersey 08534.
J Pharm Sci ; 106(11): 3222-3229, 2017 11.
Article em En | MEDLINE | ID: mdl-28634122
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Imunoglobulina G / Anticorpos Monoclonais Limite: Animals / Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Imunoglobulina G / Anticorpos Monoclonais Limite: Animals / Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2017 Tipo de documento: Article