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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists.
Carpenter, Joseph; Wang, Ying; Wu, Gang; Feng, Jianxin; Ye, Xiang-Yang; Morales, Christian L; Broekema, Matthias; Rossi, Karen A; Miller, Keith J; Murphy, Brian J; Wu, Ginger; Malmstrom, Sarah E; Azzara, Anthony V; Sher, Philip M; Fevig, John M; Alt, Andrew; Bertekap, Robert L; Cullen, Mary Jane; Harper, Timothy M; Foster, Kimberly; Luk, Emily; Xiang, Qian; Grubb, Mary F; Robl, Jeffrey A; Wacker, Dean A.
Afiliação
  • Carpenter J; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Wang Y; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Wu G; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Feng J; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Ye XY; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Morales CL; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Broekema M; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Rossi KA; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Miller KJ; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Murphy BJ; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Wu G; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Malmstrom SE; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Azzara AV; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Sher PM; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Fevig JM; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Alt A; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Bertekap RL; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Cullen MJ; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Harper TM; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Foster K; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Luk E; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Xiang Q; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Grubb MF; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Robl JA; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • Wacker DA; Departments of Discovery Chemistry, Discovery Biology, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
J Med Chem ; 60(14): 6166-6190, 2017 07 27.
Article em En | MEDLINE | ID: mdl-28635286
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Receptor 5-HT2C de Serotonina / Flavonas / Agonistas do Receptor 5-HT2 de Serotonina Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Receptor 5-HT2C de Serotonina / Flavonas / Agonistas do Receptor 5-HT2 de Serotonina Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos