Modulation of neostriatal activity by iontophoresis of ascorbic acid.
Brain Res
; 344(1): 181-5, 1985 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-2864108
ABSTRACT
Iontophoresis (20-80 nA) of ascorbic acid (AA) accelerated the firing rate of approximately one-third of the neurons tested in the anteromedial neostriatum of anesthetized rats. When administered to neostriatal neurons that were activated by the simultaneous ejection of glutamic acid (GLU), AA excited more than two-thirds of the cells examined, including many that were not excited by AA alone. At ejection currents above 80 nA, AA further increased the activity of some GLU-activated neurons, but suppressed the firing rate of others. Electrochemical quantification of AA ejection during iontophoresis indicated that the concentration of AA at the tip of the recording electrode was within reasonable physiological limits. It is concluded that endogenous AA may modulate neuronal activity in the neostriatum.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Corpo Estriado
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1985
Tipo de documento:
Article