Fluoxetine induces apoptosis through endoplasmic reticulum stress via mitogen-activated protein kinase activation and histone hyperacetylation in SK-N-BE(2)-M17 human neuroblastoma cells.

Choi, Ji Hyun; Jeong, Yeon Ju; Yu, Ah-Ran; Yoon, Kyung-Sik; Choe, Wonchae; Ha, Joohun; Kim, Sung Soo; Yeo, Eui-Ju; Kang, Insug

Choi, Ji Hyun; Jeong, Yeon Ju; Yu, Ah-Ran; Yoon, Kyung-Sik; Choe, Wonchae; Ha, Joohun; Kim, Sung Soo; Yeo, Eui-Ju; Kang, Insug.

Afiliação

Choi JH; Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 02447, Republic of Korea.
Jeong YJ; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.
Yu AR; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.
Yoon KS; Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 02447, Republic of Korea.
Choe W; Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 02447, Republic of Korea.
Ha J; Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 02447, Republic of Korea.
Kim SS; Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 02447, Republic of Korea.
Yeo EJ; Department of Biochemistry, College of Medicine, Gachon University, Incheon, 21999, Republic of Korea. euiju@gachon.ac.kr.
Kang I; Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 02447, Republic of Korea. iskang@khu.ac.kr.

Apoptosis ; 22(9): 1079-1097, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28647884

Assuntos

Acetilação/efeitos dos fármacos; Apoptose/efeitos dos fármacos; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Fluoxetina/farmacologia; Histonas/metabolismo; MAP Quinase Quinase Quinase 5/metabolismo; Neuroblastoma/patologia; Animais; Antineoplásicos/farmacologia; Caspases Iniciadoras/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Técnicas de Silenciamento de Genes; Humanos; MAP Quinase Quinase Quinase 5/genética; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos; Fosforilação; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos; Fator de Transcrição CHOP/antagonistas & inibidores; Fator de Transcrição CHOP/genética

Palavras-chave

Apoptosis; ER stress; Fluoxetine; Histone hyperacetylation; MAPKs; SK-N-BE(2)-M17 cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilação / Histonas / Fluoxetina / Apoptose / MAP Quinase Quinase Quinase 5 / Estresse do Retículo Endoplasmático / Neuroblastoma Limite: Animals / Humans Idioma: En Revista: Apoptosis Ano de publicação: 2017 Tipo de documento: Article

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