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Regioselective Synthesis of 2-Vinylanilines Using O-aroyloxycarba-mates by Sequential Decarboxylation/Amination/Heck Reaction.
Li, Peihe; Ma, Nuannuan; Li, Jikun; Wang, Zheng; Dai, Qipu; Hu, Changwen.
Afiliação
  • Li P; Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
  • Ma N; Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
  • Li J; Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
  • Wang Z; Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
  • Dai Q; Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
  • Hu C; Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic, School of Chemistry and Chemical Engineering, Beijing Institute of Technology , Beijing 100081, People's Republic of China.
J Org Chem ; 82(15): 8251-8257, 2017 08 04.
Article em En | MEDLINE | ID: mdl-28664735
A new sequential approach for 2-vinylanilines utilizing aryl carboxylic acids as stable, inexpensive and widely available arylating reagents is described. Employing a Pd-POVs catalyst system, this protocol is not only overcoming the restriction barrier of decarboxylative coupling to ortho-substituted substrates, but also provides site-special to create new C(sp2)-N and C(sp2)-C(sp2) bonds. Mechanistic experiments suggest the cleavage of C(sp2)-COOH gives priority to C(sp2)-X bond in this reaction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article