Absorption, metabolism and excretion of [<sup>14</sup>C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans.

Xu, Shiyao; Tatosian, Dan; Mcintosh, Ian; Caceres, Maria; Matthews, Catherine; Samuel, Koppara; Selverian, Diana; Kumar, Sanjeev; Kauh, Eunkyung

Absorption, metabolism and excretion of [¹⁴C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans.

Xu, Shiyao; Tatosian, Dan; Mcintosh, Ian; Caceres, Maria; Matthews, Catherine; Samuel, Koppara; Selverian, Diana; Kumar, Sanjeev; Kauh, Eunkyung.

Afiliação

Xu S; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Tatosian D; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Mcintosh I; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Caceres M; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Matthews C; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Samuel K; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Selverian D; b Department of Translational Pharmacology , MRL , Upper Gwynedd , PA , USA.
Kumar S; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, MRL , Kenilworth , NJ , USA and.
Kauh E; b Department of Translational Pharmacology , MRL , Upper Gwynedd , PA , USA.

Xenobiotica ; 48(6): 584-591, 2018 Jun.

Article em En | MEDLINE | ID: mdl-28665228

Assuntos

Isótopos de Carbono; Inibidores da Dipeptidil Peptidase IV; Compostos Heterocíclicos com 2 Anéis; Piranos; Administração Oral; Adulto; Isótopos de Carbono/administração & dosagem; Isótopos de Carbono/farmacocinética; Inibidores da Dipeptidil Peptidase IV/administração & dosagem; Inibidores da Dipeptidil Peptidase IV/farmacocinética; Compostos Heterocíclicos com 2 Anéis/administração & dosagem; Compostos Heterocíclicos com 2 Anéis/farmacocinética; Humanos; Masculino; Piranos/administração & dosagem; Piranos/farmacocinética

Palavras-chave

Accelerator mass spectrometry; DPP-4 inhibitor; human ADME; omarigliptin; once weekly; target-mediated drug disposition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piranos / Isótopos de Carbono / Inibidores da Dipeptidil Peptidase IV / Compostos Heterocíclicos com 2 Anéis Limite: Adult / Humans / Male Idioma: En Revista: Xenobiotica Ano de publicação: 2018 Tipo de documento: Article

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