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Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.
McGowan, David C; Herschke, Florence; Pauwels, Frederik; Stoops, Bart; Smyej, Ilham; Last, Stefaan; Pieters, Serge; Embrechts, Werner; Khamlichi, Mourad Daoubi; Thoné, Tine; Van Schoubroeck, Bertrand; Mostmans, Wendy; Wuyts, Debbie; Verstappen, Dorien; Scholliers, Annick; De Pooter, Dorien; Dhuyvetter, Deborah; Borghys, Herman; Tuefferd, Marianne; Arnoult, Eric; Hong, Jin; Fanning, Gregory; Bollekens, Jacques; Urmaliya, Vijay; Teisman, Ard; Horton, Helen; Jonckers, Tim H M; Raboisson, Pierre.
Afiliação
  • McGowan DC; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Herschke F; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Pauwels F; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Stoops B; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Smyej I; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Last S; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Pieters S; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Embrechts W; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Khamlichi MD; Villapharma Research S.L. , Parque Tecnológico de Fuente Álamo, Ctra. El Estrecho-Lobosillo, Km. 2.5-Av. Azul, 30320 Fuente Álamo de Murcia, Murcia, Spain.
  • Thoné T; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Van Schoubroeck B; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Mostmans W; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Wuyts D; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Verstappen D; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Scholliers A; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • De Pooter D; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Dhuyvetter D; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Borghys H; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Tuefferd M; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Arnoult E; Janssen Research & Development L.L.C. , 1400 McKean Road, Spring House, Pennsylvania 19454, United States.
  • Hong J; Alios Biopharma, Inc. , 260 East Grand Avenue, South San Francisco, California 94080, United States.
  • Fanning G; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Bollekens J; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Urmaliya V; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Teisman A; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Horton H; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Jonckers THM; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Raboisson P; Janssen Pharmaceutica , N. V. Turnhoutseweg 30, 2340 Beerse, Belgium.
J Med Chem ; 60(14): 6137-6151, 2017 07 27.
Article em En | MEDLINE | ID: mdl-28671847
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas / Pirróis / Receptor 7 Toll-Like / Hepatite B Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas / Pirróis / Receptor 7 Toll-Like / Hepatite B Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica