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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Corte, James R; Yang, Wu; Fang, Tianan; Wang, Yufeng; Osuna, Honey; Lai, Amy; Ewing, William R; Rossi, Karen A; Myers, Joseph E; Sheriff, Steven; Lou, Zhen; Zheng, Joanna J; Harper, Timothy W; Bozarth, Jeffrey M; Wu, Yiming; Luettgen, Joseph M; Seiffert, Dietmar A; Quan, Mimi L; Wexler, Ruth R; Lam, Patrick Y S.
Afiliação
  • Corte JR; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States. Electronic address: james.corte@bms.com.
  • Yang W; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States. Electronic address: wu.yang@bms.com.
  • Fang T; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Wang Y; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Osuna H; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Lai A; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Ewing WR; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Rossi KA; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Myers JE; Bristol-Myers Squibb Company, Research and Development, US Rt. 206 & Province Line Road, Princeton, NJ 08540, United States.
  • Sheriff S; Bristol-Myers Squibb Company, Research and Development, US Rt. 206 & Province Line Road, Princeton, NJ 08540, United States.
  • Lou Z; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Zheng JJ; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Harper TW; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Bozarth JM; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Wu Y; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Luettgen JM; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Seiffert DA; Bristol-Myers Squibb Company, Research and Development, 311 Pennington-Rocky Hill Road, Pennington, NJ 08543-2130, United States.
  • Quan ML; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Wexler RR; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
  • Lam PYS; Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.
Bioorg Med Chem Lett ; 27(16): 3833-3839, 2017 08 15.
Article em En | MEDLINE | ID: mdl-28687203
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator XIa / Inibidores de Serina Proteinase / Compostos Macrocíclicos / Descoberta de Drogas / Amidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator XIa / Inibidores de Serina Proteinase / Compostos Macrocíclicos / Descoberta de Drogas / Amidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article