Pancreatic ß-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

Cunha, Daniel A; Cito, Monia; Grieco, Fabio Arturo; Cosentino, Cristina; Danilova, Tatiana; Ladrière, Laurence; Lindahl, Maria; Domanskyi, Andrii; Bugliani, Marco; Marchetti, Piero; Eizirik, Décio L; Cnop, Miriam

Cunha, Daniel A; Cito, Monia; Grieco, Fabio Arturo; Cosentino, Cristina; Danilova, Tatiana; Ladrière, Laurence; Lindahl, Maria; Domanskyi, Andrii; Bugliani, Marco; Marchetti, Piero; Eizirik, Décio L; Cnop, Miriam.

Afiliação

Cunha DA; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Cito M; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Grieco FA; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Cosentino C; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Danilova T; the Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.
Ladrière L; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Lindahl M; the Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.
Domanskyi A; the Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.
Bugliani M; the Department of Endocrinology and Metabolism, University of Pisa, 56100 Pisa, Italy, and.
Marchetti P; the Department of Endocrinology and Metabolism, University of Pisa, 56100 Pisa, Italy, and.
Eizirik DL; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Cnop M; From the Université Libre de Bruxelles Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium, mcnop@ulb.ac.be.

J Biol Chem ; 292(36): 14977-14988, 2017 09 08.

Article em En | MEDLINE | ID: mdl-28698383

Assuntos

Inflamação/metabolismo; Células Secretoras de Insulina/metabolismo; Fatores de Crescimento Neural/metabolismo; Trombospondina 1/metabolismo; Animais; Células Cultivadas; Citocinas/metabolismo; Retículo Endoplasmático/metabolismo; Humanos; Células Secretoras de Insulina/efeitos dos fármacos; Camundongos; Fatores de Crescimento Neural/antagonistas & inibidores; Estresse Oxidativo; Tapsigargina/farmacologia

Palavras-chave

IL-1; cytokine; endoplasmic reticulum stress (ER stress); inflammation; interferon; islet; mitochondrial apoptosis; thrombospondin; type 1 diabetes; ß-cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombospondina 1 / Células Secretoras de Insulina / Inflamação / Fatores de Crescimento Neural Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Bélgica

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