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A weight-independent association between atypical antipsychotic medications and obstructive sleep apnea.
Khazaie, Habibolah; Sharafkhaneh, Amir; Khazaie, Sepideh; Ghadami, Mohammad Rasoul.
Afiliação
  • Khazaie H; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Sharafkhaneh A; Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
  • Khazaie S; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Ghadami MR; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. mr_ghadami@yahoo.com.
Sleep Breath ; 22(1): 109-114, 2018 03.
Article em En | MEDLINE | ID: mdl-28707161
ABSTRACT

BACKGROUND:

With increasing use of atypical antipsychotic (AAP) agents, the concern has been raised about the association between AAP agents and medical complications. Obstructive sleep apnea (OSA) is a common breathing disorder that adversely affects health and quality of life. Because the major risk factors for OSA are weight gain and obesity by altering the upper airway anatomy, an association between AAP and development of OSA is predictable. However, we hypothesized that AAP may promote OSA not only by weight gain but also because of its potential effects on upper airway muscle function. In the present study, we evaluated the possible association between AAP use and the severity of OSA.

METHODS:

A sample of patients using AAP for treatment of paradoxical insomnia was evaluated before and at least 8 weeks after AAP use. Patients were divided based on type of AAP use to olanzapine, risperidone, and quetiapine groups. Patients used olanzapine (5-10 mg), risperidone (2-4 mg), or quetiapine (100-200 mg) 2 h before bedtime. Before and after treatment, respiratory variables were recorded using polysomnography. BMI, neck circumference (NC), and waist circumference (WC) were measured before and after treatment period.

RESULTS:

There was no significant difference between pre- and post-treatment apnea index (0.2 ± 0.6 vs. 2.6 ± 4.3; p = 0.094) in olanzapine group. However, significant differences in hypopnea index (5.1 ± 5 vs. 30 ± 10.8; p < 0.0001) and AHI (5.3 ± 4.9 vs. 32.6 ± 9.6; p < 0.0001) were observed. Similar results were found in quetiapine and risperidone groups, except that in quetiapine group, apnea index was significantly increased after treatment period (0.7 ± 1.2 in pre-treatment vs. 3.1 ± 2.4 in post-treatment; p = 0.007). There were no significant changes in BMI, NC, and WC during treatment period in all three groups.

CONCLUSION:

While AAP medications are known cause of weight gain as a main risk factor of OSA, our finding demonstrated a weight-independent association between AAP medications and worsening respiration during sleep.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antipsicóticos / Apneia Obstrutiva do Sono Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Breath Assunto da revista: NEUROLOGIA / OTORRINOLARINGOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Irã

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antipsicóticos / Apneia Obstrutiva do Sono Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Breath Assunto da revista: NEUROLOGIA / OTORRINOLARINGOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Irã