CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
Cell Syst
; 5(1): 82-86.e3, 2017 07 26.
Article
em En
| MEDLINE
| ID: mdl-28711281
ABSTRACT
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Genótipo
/
Recursos em Saúde
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Cell Syst
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Irlanda