Redox regulation of proteasome function.
Redox Biol
; 13: 452-458, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28715730
ABSTRACT
Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations. This short review summarizes the effects of oxidative stress on proteasome status while it also recapitulates conditions and processes where redox alterations signal changes to proteasome expression, assembly and function.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peroxissomos
/
Complexo de Endopeptidases do Proteassoma
/
Homeostase
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Grécia