An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems.
J Pharm Biomed Anal
; 147: 350-366, 2018 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-28720350
ABSTRACT
In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Química Farmacêutica
/
Sistemas de Liberação de Medicamentos
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Liberação Controlada de Fármacos
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Mucosa
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
2018
Tipo de documento:
Article