Deficiency of PI3-Kinase catalytic isoforms p110Î³ and p110Î´ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.

Bucher, Kirsten; Schmitt, Fee; Mothes, Benedikt; Blumendeller, Carolin; Schäll, Daniel; Piekorz, Roland; Hirsch, Emilio; Nürnberg, Bernd; Beer-Hammer, Sandra

Bucher, Kirsten; Schmitt, Fee; Mothes, Benedikt; Blumendeller, Carolin; Schäll, Daniel; Piekorz, Roland; Hirsch, Emilio; Nürnberg, Bernd; Beer-Hammer, Sandra.

Afiliação

Bucher K; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany.
Schmitt F; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany.
Mothes B; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany.
Blumendeller C; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany.
Schäll D; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany.
Piekorz R; Institute of Biochemistry and Molecular Biology II, University of Düsseldorf, D-40225, Düsseldorf, Germany.
Hirsch E; Department of Genetics, Biology and Biochemistry, University of Torino, I-10126, Torino, Italy.
Nürnberg B; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany.
Beer-Hammer S; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA mouse clinic, University of Tübingen, D-72074, Tübingen, Germany. sandra.beer-hammer@uni-tuebingen.de.

Cell Commun Signal ; 15(1): 28, 2017 07 19.

Article em En | MEDLINE | ID: mdl-28724384

Assuntos

Transtornos Leucocíticos/genética; Neutrófilos/metabolismo; Fosfatidilinositol 3-Quinases/deficiência; Animais; Células Cultivadas; Quimiocina CXCL1/metabolismo; Quimiocina CXCL2/metabolismo; Fator Estimulador de Colônias de Granulócitos/metabolismo; Homeostase; Interleucina-17/metabolismo; Isoenzimas/deficiência; Isoenzimas/genética; Isoenzimas/metabolismo; Transtornos Leucocíticos/metabolismo; Pulmão/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Baço/metabolismo; Linfócitos T/metabolismo

Palavras-chave

G-CSF; IL-17-producing T cells; Il-17; PI3K p110Î³; PI3K p110Î´,neutrophil homeostasis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Transtornos Leucocíticos / Neutrófilos Limite: Animals Idioma: En Revista: Cell Commun Signal Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha

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