The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.

Gnerre, Carmela; Segrestaa, Jérôme; Seeland, Swen; Äänismaa, Päivi; Pfeifer, Thomas; Delahaye, Stephane; de Kanter, Ruben; Ichikawa, Tomohiko; Yamada, Tetsuhiro; Treiber, Alexander

Gnerre, Carmela; Segrestaa, Jérôme; Seeland, Swen; Äänismaa, Päivi; Pfeifer, Thomas; Delahaye, Stephane; de Kanter, Ruben; Ichikawa, Tomohiko; Yamada, Tetsuhiro; Treiber, Alexander.

Afiliação

Gnerre C; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
Segrestaa J; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
Seeland S; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
Äänismaa P; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
Pfeifer T; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
Delahaye S; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
de Kanter R; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.
Ichikawa T; b Pharmacokinetics and Safety Assessment Dept , Nippon Shinyaku Co , Kyoto , Japan.
Yamada T; b Pharmacokinetics and Safety Assessment Dept , Nippon Shinyaku Co , Kyoto , Japan.
Treiber A; a Preclinical Pharmacokinetics and Metabolism, Actelion Pharmaceuticals Ltd , Allschwil , Switzerland and.

Xenobiotica ; 48(7): 704-719, 2018 Jul.

Article em En | MEDLINE | ID: mdl-28737453

Assuntos

Acetamidas/metabolismo; Acetamidas/farmacologia; Pirazinas/metabolismo; Pirazinas/farmacologia; Receptores de Epoprostenol/agonistas; Acetamidas/sangue; Acetamidas/química; Acetatos/farmacologia; Interações Medicamentosas; Inibidores Enzimáticos/farmacologia; Esterases/antagonistas & inibidores; Esterases/metabolismo; Hepatócitos/metabolismo; Humanos; Proteínas de Membrana Transportadoras/metabolismo; Redes e Vias Metabólicas/efeitos dos fármacos; Metaboloma; Metabolômica; Microssomos Hepáticos/efeitos dos fármacos; Microssomos Hepáticos/metabolismo; NADP/metabolismo; Pirazinas/sangue; Pirazinas/química; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptores de Epoprostenol/metabolismo; Proteínas Recombinantes/metabolismo

Palavras-chave

Cytochrome P450; drug interaction; drug transporter; metabolism in man; prostacyclin receptor agonist; selexipagl

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Receptores de Epoprostenol / Acetamidas Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2018 Tipo de documento: Article

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