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Neuroactive steroids and diabetic complications in the nervous system.
Giatti, S; Mastrangelo, R; D'Antonio, M; Pesaresi, M; Romano, S; Diviccaro, S; Caruso, D; Mitro, N; Melcangi, R C.
Afiliação
  • Giatti S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Mastrangelo R; Division of Genetic and Cell Biology, San Raffaele Scientific Institute, DIBIT, Milano, Italy.
  • D'Antonio M; Division of Genetic and Cell Biology, San Raffaele Scientific Institute, DIBIT, Milano, Italy.
  • Pesaresi M; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Romano S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Diviccaro S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Caruso D; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Mitro N; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
  • Melcangi RC; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy. Electronic address: roberto.melcangi@unimi.it.
Front Neuroendocrinol ; 48: 58-69, 2018 01.
Article em En | MEDLINE | ID: mdl-28739507
Important complications of diabetes mellitus in the nervous system are represented by diabetic peripheral neuropathy and diabetic encephalopathy. In this context, an important link is represented by neuroactive steroids (i.e., steroids coming from peripheral glands and affecting nervous functionality as well as directly synthesized in the nervous system). Indeed, diabetes does not only affect the reproductive axis and consequently the levels of sex steroid hormones, but also those of neuroactive steroids. Indeed, as will be here summarized, the levels of these neuromodulators present in the central and peripheral nervous system are affected by the pathology in a sex-dimorphic way. In addition, some of these neuroactive steroids, such as the metabolites of progesterone or testosterone, as well as pharmacological tools able to increase their levels have been demonstrated, in experimental models, to be promising protective agents against diabetic peripheral neuropathy and diabetic encephalopathy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Neuropeptídeos / Encefalopatias / Caracteres Sexuais / Complicações do Diabetes / Neuropatias Diabéticas / Bainha de Mielina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Front Neuroendocrinol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Neuropeptídeos / Encefalopatias / Caracteres Sexuais / Complicações do Diabetes / Neuropatias Diabéticas / Bainha de Mielina Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Front Neuroendocrinol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália