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Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether.
Kuethe, Jeffrey T; Basu, Kallol; Orr, Robert K; Ashley, Eric; Poirier, Marc; Tan, Lushi.
Afiliação
  • Kuethe JT; Department of Process Research and Development, Merck & Co., Inc, Kenilworth, NJ 07033, USA. Electronic address: Jeffrey_Kuethe@merck.com.
  • Basu K; Department of Process Research and Development, Merck & Co., Inc, Kenilworth, NJ 07033, USA.
  • Orr RK; Department of Process Research and Development, Merck & Co., Inc, Kenilworth, NJ 07033, USA.
  • Ashley E; Department of Process Research and Development, Merck & Co., Inc, Kenilworth, NJ 07033, USA.
  • Poirier M; Department of Process Research and Development, Merck & Co., Inc, Kenilworth, NJ 07033, USA.
  • Tan L; Department of Process Research and Development, Merck & Co., Inc, Kenilworth, NJ 07033, USA.
Bioorg Med Chem ; 26(4): 938-944, 2018 02 15.
Article em En | MEDLINE | ID: mdl-28751197
ABSTRACT
The evolution of a scalable process for the preparation of methylcyclobutanol-pyridyl ether 1 is described. Key aspects of this development including careful control of the stereochemistry, elimination of chromatography, and application to kilogram-scale synthesis are addressed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclobutanos / Éteres Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclobutanos / Éteres Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article