Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians.
Mech Ageing Dev
; 168: 54-57, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-28754532
ABSTRACT
Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Furthermore, factors involved in the control of these miRNAs biogenesis genes are also up-regulated in centenarians. Therefore, the up-regulation of miRNA expression in centenarians can be explained in part because miRNA biogenesis pathway is depressed in octogenarians (ordinary aging) while it is maintained in centenarians (extraordinary aging).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
MicroRNAs
Limite:
Aged80
/
Humans
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha