Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness.
J Neurogenet
; 31(4): 266-287, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-28762842
ABSTRACT
Eating-disorders (EDs) consequences to human health are devastating, involving social, mental, emotional, physical and life-threatening aspects, concluding on impairment and death in cases of extreme anorexia nervosa. It also implies that people suffering an ED need to find psychiatric and psychological help as soon as possible to achieve a fully physical and emotional recovery. Unfortunately, to date, there is a crucial lack of efficient clinical treatment to these disorders. In this review, we present an overview concerning the actual pharmacological and psychological treatments, the knowledge of cells, circuits, neuropeptides, neuromodulators and hormones in the human brain- and other organs- underlying these disorders, the studies in animal models and, finally, the genetic approaches devoted to face this challenge. We will also discuss the need for new perspectives, avenues and strategies to be developed in order to pave the way to novel and more efficient therapeutics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anorexia Nervosa
/
Bulimia Nervosa
/
Transtorno da Compulsão Alimentar
Limite:
Humans
Idioma:
En
Revista:
J Neurogenet
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha