Investigating the susceptibility of mice to a bacterial challenge after intravenous exposure to durable nanoparticles.
Nanomedicine (Lond)
; 12(17): 2097-2111, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28805153
ABSTRACT
AIM:
The goal of this study was to determine whether bacterial clearance in a rodent model would be impaired upon exposure to gold, silver or silica nanoparticles (NPs). MATERIALS &METHODS:
Mice received weekly injections of NPs followed by a challenge of Listeria monocytogenes (LM). On days 3 and 10 after LM injections, the animals were sacrificed and their tissues were collected for elemental analysis, electron microscopy and LM count determination.RESULTS:
The untreated and NP-treated animals cleared LM at the same rate suggesting that bioaccumulation of NPs did not increase the animals' susceptibility to bacterial infection.CONCLUSION:
The data from this study indicate that the bioaccumulation of NPs does not significantly affect the ability to react to a bacterial challenge.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
/
Listeriose
/
Listeria monocytogenes
Limite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Nanomedicine (Lond)
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos