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Effects of low-dose irradiation on mice with Escherichia coli-induced sepsis.
Song, Kyung-Hee; Jung, Seung-Youn; Kho, Seong-Ho; Hwang, Sang-Gu; Ha, Hunjoo; Nam, Seon Young; Song, Jie-Young.
Afiliação
  • Song KH; Division of Applied Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of
  • Jung SY; Division of Applied Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea.
  • Kho SH; Division of Applied Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea.
  • Hwang SG; Division of Applied Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea.
  • Ha H; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
  • Nam SY; Low-Dose Radiation Research Team, Radiation Health Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul 01450, Republic of Korea.
  • Song JY; Division of Applied Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea. Electronic address: immu@kirams.re.kr.
Toxicol Appl Pharmacol ; 333: 17-25, 2017 10 15.
Article em En | MEDLINE | ID: mdl-28818514
Although favorable immune responses to low-dose irradiation (LDI) have been observed in normal mice, i.e., a hormesis effect, little is known about the effects of LDI in infectious diseases. In this study, we examined the effects of LDI on mice with sepsis, a severe and often lethal hyperinflammatory response to bacteria. Female C57BL/6 mice were whole-body irradiated with 10cGy 48h before Escherichia coli infection, and survival, bacterial clearance, cytokines, and antioxidants were quantified. LDI pretreatment significantly increased survival from 46.7% in control mice to 75% in mice with sepsis. The bacterial burden was significantly lower in the blood, spleen, and kidney of LDI-treated mice than in those of control septic mice. The levels of pro-inflammatory cytokines, e.g., IL-1ß and IL-6, as well as anti-inflammatory IL-10 were markedly reduced in pre-LDI septic mice. Nitric oxide production by peritoneal macrophages was also reduced in pre-LDI septic mice. Immune cells in the spleen increased and Nrf2 and HO-1 were induced in pre-LDI septic mice. LDI stimulates the immune response and minimizes lethality in septic mice via enhanced bacterial clearance and reduced initial proinflammatory responses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Irradiação Corporal Total / Sepse / Infecções por Escherichia coli Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Irradiação Corporal Total / Sepse / Infecções por Escherichia coli Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2017 Tipo de documento: Article