Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity.

Kormann, Michael S D; Dewerth, Alexander; Eichner, Felizitas; Baskaran, Praveen; Hector, Andreas; Regamey, Nicolas; Hartl, Dominik; Handgretinger, Rupert; Antony, Justin S

Kormann, Michael S D; Dewerth, Alexander; Eichner, Felizitas; Baskaran, Praveen; Hector, Andreas; Regamey, Nicolas; Hartl, Dominik; Handgretinger, Rupert; Antony, Justin S.

Afiliação

Kormann MSD; Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany.
Dewerth A; Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany.
Eichner F; Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany.
Baskaran P; Center for Quantitative Biology, University of Tuebingen, Tuebingen, Germany.
Hector A; University Children's Clinic Department of Paediatrics I, Paediatric Infectiology & Immunology, University of Tuebingen, Tuebingen, Germany.
Regamey N; Division of Paediatric Respiratory Medicine and Department of Clinical Research, University of Bern, Bern, Switzerland.
Hartl D; Children's Hopsital of Lucerne, Paediatric Pulmonology, Lucerne, Switzerland.
Handgretinger R; University Children's Clinic Department of Paediatrics I, Paediatric Infectiology & Immunology, University of Tuebingen, Tuebingen, Germany.
Antony JS; University Children's Clinic Department of Paediatrics I, Hematology and Oncology, University of Tuebingen, Tuebingen, Germany.

PLoS One ; 12(8): e0183526, 2017.

Article em En | MEDLINE | ID: mdl-28846703

Assuntos

Fibrose Cística/genética; Genótipo; Interferon Tipo I/genética; Proteínas Ribossômicas/genética; Transcriptoma; Adolescente; Adulto; Criança; Fibrose Cística/diagnóstico; Feminino; Humanos; Masculino; Mutação; Fenótipo; Índice de Gravidade de Doença; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Ribossômicas / Interferon Tipo I / Fibrose Cística / Transcriptoma / Genótipo Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha

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