The role of angiogenic markers in adverse perinatal outcomes: fresh versus frozen embryo transfers.
J Assist Reprod Genet
; 34(12): 1639-1643, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28871422
ABSTRACT
PURPOSE:
We aimed to investigate the angiogenic balance in fresh compared to frozen embryo transfers, and among neonates with adverse perinatal outcomes.METHODS:
This was a retrospective cohort study. All IVF cycles resulting in a singleton live birth at a university academic fertility center from January 1, 2011, to December 31, 2013, were examined. Concentrations of sFLT-1 and PlGF were measured in previously frozen serum specimens collected during early gestation at approximately 5 weeks gestation. Patients completed an electronic survey to detail perinatal outcome.RESULTS:
We identified 152 singleton live births (103 fresh, 49 frozen). Demographic characteristics were similar between the two groups. Ratios of sFlt-1PlGF were not different between fresh and frozen transfers. Neonates from fresh cycles had a mean birth weight 202 g lighter (p = 0.01) than frozen cycles, after adjusting for gestational age. Among babies born with poor perinatal outcomes, there was a difference in sFlt-1PlGF ratios after adjusting for race. In non-Asians, infants born small for gestational age (SGA) (< 10th percentile) had significantly higher sFLT-1PLGF ratio, median ratio (0.21 vs 0.12, p = 0.016).CONCLUSIONS:
Fresh transfers were associated with lower birth weight infants compared to frozen transfers. While there was no difference in sFlt-1PlGF ratios between fresh and frozen transfers, these ratios were significantly lower in SGA infants, suggesting an imbalance in angiogenic markers during placentation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Pequeno para a Idade Gestacional
/
Fertilização in vitro
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Criopreservação
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Receptor 1 de Fatores de Crescimento do Endotélio Vascular
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Transferência Embrionária
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Fator de Crescimento Placentário
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Infertilidade Feminina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
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Newborn
/
Pregnancy
Idioma:
En
Revista:
J Assist Reprod Genet
Assunto da revista:
GENETICA
/
MEDICINA REPRODUTIVA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos