Elongation Factor P and the Control of Translation Elongation.
Annu Rev Microbiol
; 71: 117-131, 2017 09 08.
Article
em En
| MEDLINE
| ID: mdl-28886684
Elongation factor P (EF-P) binds to ribosomes requiring assistance with the formation of oligo-prolines. In order for EF-P to associate with paused ribosomes, certain tRNAs with specific d-arm residues must be present in the peptidyl site, e.g., tRNAPro. Once EF-P is accommodated into the ribosome and bound to Pro-tRNAPro, productive synthesis of the peptide bond occurs. The underlying mechanism by which EF-P facilitates this reaction seems to have entropic origins. Maximal activity of EF-P requires a posttranslational modification in Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. Each of these modifications is distinct and ligated onto its respective EF-P through entirely convergent means. Here we review the facets of translation elongation that are controlled by EF-P, with a particular focus on the purpose behind the many different modifications of EF-P.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Elongação Traducional da Cadeia Peptídica
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Pseudomonas aeruginosa
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Bacillus subtilis
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Fatores de Alongamento de Peptídeos
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Escherichia coli
Idioma:
En
Revista:
Annu Rev Microbiol
Ano de publicação:
2017
Tipo de documento:
Article