Your browser doesn't support javascript.
loading
Elongation Factor P and the Control of Translation Elongation.
Rajkovic, Andrei; Ibba, Michael.
Afiliação
  • Rajkovic A; Molecular, Cellular and Developmental Biology Program and Center for RNA Biology, Ohio State University, Columbus, Ohio 43210; email: ibba.1@osu.edu.
  • Ibba M; Molecular, Cellular and Developmental Biology Program and Center for RNA Biology, Ohio State University, Columbus, Ohio 43210; email: ibba.1@osu.edu.
Annu Rev Microbiol ; 71: 117-131, 2017 09 08.
Article em En | MEDLINE | ID: mdl-28886684
Elongation factor P (EF-P) binds to ribosomes requiring assistance with the formation of oligo-prolines. In order for EF-P to associate with paused ribosomes, certain tRNAs with specific d-arm residues must be present in the peptidyl site, e.g., tRNAPro. Once EF-P is accommodated into the ribosome and bound to Pro-tRNAPro, productive synthesis of the peptide bond occurs. The underlying mechanism by which EF-P facilitates this reaction seems to have entropic origins. Maximal activity of EF-P requires a posttranslational modification in Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. Each of these modifications is distinct and ligated onto its respective EF-P through entirely convergent means. Here we review the facets of translation elongation that are controlled by EF-P, with a particular focus on the purpose behind the many different modifications of EF-P.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elongação Traducional da Cadeia Peptídica / Pseudomonas aeruginosa / Bacillus subtilis / Fatores de Alongamento de Peptídeos / Escherichia coli Idioma: En Revista: Annu Rev Microbiol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elongação Traducional da Cadeia Peptídica / Pseudomonas aeruginosa / Bacillus subtilis / Fatores de Alongamento de Peptídeos / Escherichia coli Idioma: En Revista: Annu Rev Microbiol Ano de publicação: 2017 Tipo de documento: Article