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Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model.
Yamamoto, Yumi; Välitalo, Pyry A; Huntjens, Dymphy R; Proost, Johannes H; Vermeulen, An; Krauwinkel, Walter; Beukers, Margot W; van den Berg, Dirk-Jan; Hartman, Robin; Wong, Yin Cheong; Danhof, Meindert; van Hasselt, John G C; de Lange, Elizabeth C M.
Afiliação
  • Yamamoto Y; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Välitalo PA; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Huntjens DR; Quantitative Sciences, Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Proost JH; Division of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands.
  • Vermeulen A; Quantitative Sciences, Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Krauwinkel W; Department of Clinical Pharmacology and Exploratory Development, Astellas Pharma BV, Leiden, The Netherlands.
  • Beukers MW; Science Business Support, Leiden, the Netherlands.
  • van den Berg DJ; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Hartman R; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Wong YC; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Danhof M; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • van Hasselt JGC; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • de Lange ECM; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
CPT Pharmacometrics Syst Pharmacol ; 6(11): 765-777, 2017 11.
Article em En | MEDLINE | ID: mdl-28891201
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Central / Bibliotecas de Moléculas Pequenas / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Central / Bibliotecas de Moléculas Pequenas / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda