N-terminal splicing extensions of the human <i>MYO1C</i> gene fine-tune the kinetics of the three full-length myosin IC isoforms.

Zattelman, Lilach; Regev, Ronit; Usaj, Marko; Reinke, Patrick Y A; Giese, Sven; Samson, Abraham O; Taft, Manuel H; Manstein, Dietmar J; Henn, Arnon

N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.

Zattelman, Lilach; Regev, Ronit; Usaj, Marko; Reinke, Patrick Y A; Giese, Sven; Samson, Abraham O; Taft, Manuel H; Manstein, Dietmar J; Henn, Arnon.

Afiliação

Zattelman L; From the Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Regev R; From the Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Usaj M; From the Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Reinke PYA; the Institute for Biophysical Chemistry, Hannover Medical School, OE 4350, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Giese S; the Institute for Biophysical Chemistry, Hannover Medical School, OE 4350, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Samson AO; the Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 1311520, Israel, and.
Taft MH; the Institute for Biophysical Chemistry, Hannover Medical School, OE 4350, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Manstein DJ; the Institute for Biophysical Chemistry, Hannover Medical School, OE 4350, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Henn A; From the Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel, arnon.henn@technion.ac.il.

J Biol Chem ; 292(43): 17804-17818, 2017 10 27.

Article em En | MEDLINE | ID: mdl-28893906

Assuntos

Processamento Alternativo; Miosina Tipo I; Actomiosina/química; Actomiosina/genética; Actomiosina/metabolismo; Difosfato de Adenosina/química; Difosfato de Adenosina/genética; Difosfato de Adenosina/metabolismo; Substituição de Aminoácidos; Cristalografia por Raios X; Células HEK293; Humanos; Isoenzimas; Mutação de Sentido Incorreto; Miosina Tipo I/química; Miosina Tipo I/genética; Miosina Tipo I/metabolismo

Palavras-chave

MYO1C; NMI; enzyme mechanism; molecular modeling; molecular motor; myosin; pre-steady-state kinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento Alternativo / Miosina Tipo I Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Israel

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