Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Science
; 357(6356): 1156-1160, 2017 09 15.
Article
em En
| MEDLINE
| ID: mdl-28912244
ABSTRACT
Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria. In a colon cancer mouse model, gemcitabine resistance was induced by intratumor Gammaproteobacteria, dependent on bacterial CDDL expression, and abrogated by cotreatment with the antibiotic ciprofloxacin. Gemcitabine is commonly used to treat pancreatic ductal adenocarcinoma (PDAC), and we hypothesized that intratumor bacteria might contribute to drug resistance of these tumors. Consistent with this possibility, we found that of the 113 human PDACs that were tested, 86 (76%) were positive for bacteria, mainly Gammaproteobacteria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Resistencia a Medicamentos Antineoplásicos
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Carcinoma Ductal Pancreático
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Desoxicitidina
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Antimetabólitos Antineoplásicos
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Science
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Israel