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Total Synthesis of Glycinocins A-C.
Corcilius, Leo; Elias, Nabiha T; Ochoa, Jessica L; Linington, Roger G; Payne, Richard J.
Afiliação
  • Corcilius L; School of Chemistry, The University of Sydney , Sydney, NSW 2006, Australia.
  • Elias NT; School of Chemistry, The University of Sydney , Sydney, NSW 2006, Australia.
  • Ochoa JL; Department of Chemistry and Biochemistry, University of California, Santa Cruz , 1156 High Street, Santa Cruz, California 95064, United States.
  • Linington RG; Department of Chemistry and Biochemistry, University of California, Santa Cruz , 1156 High Street, Santa Cruz, California 95064, United States.
  • Payne RJ; Department of Chemistry, Simon Fraser University , Burnaby, British Columbia V5A 1S6, Canada.
J Org Chem ; 82(23): 12778-12785, 2017 12 01.
Article em En | MEDLINE | ID: mdl-28914054
ABSTRACT
The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clinically approved daptomycin. Herein, we describe a divergent total synthesis of glycinocins A-C, which differ in the structure of a branched α,ß-unsaturated fatty acyl moiety. The three natural products exhibited calcium-dependent antimicrobial activity against Staphylococcus aureus and Bacillus subtilis with MICs ranging from 5.5 to 17 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antibacterianos Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antibacterianos Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália