Tissue regeneration using endothelial colony-forming cells: promising cells for vascular repair.
Pediatr Res
; 83(1-2): 283-290, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-28915234
ABSTRACT
Repairing and rebuilding damaged tissue in diseased human subjects remains a daunting challenge for clinical medicine. Proper vascular formation that serves to deliver blood-borne nutrients and adequate levels of oxygen and to remove wastes is critical for successful tissue regeneration. Endothelial colony-forming cells (ECFC) represent a promising cell source for revascularization of damaged tissue. ECFCs are identified by displaying a hierarchy of clonal proliferative potential and by pronounced postnatal vascularization ability in vivo. In this review, we provide a brief overview of human ECFC isolation and characterization, a survey of a number of animal models of human disease in which ECFCs have been shown to have prominent roles in tissue repair, and a summary of current challenges that must be overcome before moving ECFC into human subjects as a cell therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Endotélio Vascular
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Células Endoteliais
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Medicina Regenerativa
Limite:
Animals
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Humans
Idioma:
En
Revista:
Pediatr Res
Ano de publicação:
2018
Tipo de documento:
Article