Big Lessons from Little Yeast: Budding and Fission Yeast Centrosome Structure, Duplication, and Function.
Annu Rev Genet
; 51: 361-383, 2017 11 27.
Article
em En
| MEDLINE
| ID: mdl-28934593
ABSTRACT
Centrosomes are a functionally conserved feature of eukaryotic cells that play an important role in cell division. The conserved γ-tubulin complex organizes spindle and astral microtubules, which, in turn, separate replicated chromosomes accurately into daughter cells. Like DNA, centrosomes are duplicated once each cell cycle. Although in some cell types it is possible for cell division to occur in the absence of centrosomes, these divisions typically result in defects in chromosome number and stability. In single-celled organisms such as fungi, centrosomes [known as spindle pole bodies (SPBs)] are essential for cell division. SPBs also must be inserted into the membrane because fungi undergo a closed mitosis in which the nuclear envelope (NE) remains intact. This poorly understood process involves events similar or identical to those needed for de novo nuclear pore complex assembly. Here, we review how analysis of fungal SPBs has advanced our understanding of centrosomes and NE events.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Schizosaccharomyces
/
Regulação Fúngica da Expressão Gênica
/
Centrossomo
/
Corpos Polares do Fuso
/
Microtúbulos
Idioma:
En
Revista:
Annu Rev Genet
Ano de publicação:
2017
Tipo de documento:
Article