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Reconstructing Prehistoric African Population Structure.
Skoglund, Pontus; Thompson, Jessica C; Prendergast, Mary E; Mittnik, Alissa; Sirak, Kendra; Hajdinjak, Mateja; Salie, Tasneem; Rohland, Nadin; Mallick, Swapan; Peltzer, Alexander; Heinze, Anja; Olalde, Iñigo; Ferry, Matthew; Harney, Eadaoin; Michel, Megan; Stewardson, Kristin; Cerezo-Román, Jessica I; Chiumia, Chrissy; Crowther, Alison; Gomani-Chindebvu, Elizabeth; Gidna, Agness O; Grillo, Katherine M; Helenius, I Taneli; Hellenthal, Garrett; Helm, Richard; Horton, Mark; López, Saioa; Mabulla, Audax Z P; Parkington, John; Shipton, Ceri; Thomas, Mark G; Tibesasa, Ruth; Welling, Menno; Hayes, Vanessa M; Kennett, Douglas J; Ramesar, Raj; Meyer, Matthias; Pääbo, Svante; Patterson, Nick; Morris, Alan G; Boivin, Nicole; Pinhasi, Ron; Krause, Johannes; Reich, David.
Afiliação
  • Skoglund P; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: skoglund@genetics.med.harvard.edu.
  • Thompson JC; Department of Anthropology, Emory University, Atlanta, GA 30322, USA.
  • Prendergast ME; Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA 02138, USA.
  • Mittnik A; Max Planck Institute for the Science of Human History, Jena 07745, Germany; Institute for Archeological Sciences, Eberhard-Karls-University, Tuebingen 72070, Germany.
  • Sirak K; Department of Anthropology, Emory University, Atlanta, GA 30322, USA; School of Archaeology and Earth Institute, University College Dublin, Dublin 4, Ireland.
  • Hajdinjak M; Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
  • Salie T; Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
  • Rohland N; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Mallick S; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Peltzer A; Max Planck Institute for the Science of Human History, Jena 07745, Germany; Integrative Transcriptomics, Centre for Bioinformatics, University of Tuebingen, Tuebingen 72076, Germany.
  • Heinze A; Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
  • Olalde I; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Ferry M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Harney E; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Michel M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Stewardson K; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Cerezo-Román JI; Department of Geography and Anthropology, California State Polytechnic University, Pomona, Pomona, CA 91768, USA.
  • Chiumia C; Malawi Department of Museums and Monuments, Lilongwe 3, Malawi.
  • Crowther A; Max Planck Institute for the Science of Human History, Jena 07745, Germany; School of Social Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Gomani-Chindebvu E; Malawi Department of Museums and Monuments, Lilongwe 3, Malawi.
  • Gidna AO; National Museums of Tanzania, Dar es Salaam, Tanzania.
  • Grillo KM; Department of Archaeology and Anthropology, University of Wisconsin - La Crosse, La Crosse, WI 54601, USA.
  • Helenius IT; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
  • Hellenthal G; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
  • Helm R; Canterbury Archaeological Trust, Canterbury CT1 2LU, UK.
  • Horton M; Department Archaeology and Anthropology, University of Bristol, Bristol BS8 1UU, UK.
  • López S; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
  • Mabulla AZP; National Museums of Tanzania, Dar es Salaam, Tanzania.
  • Parkington J; Department of Archaeology, University of Cape Town, Cape Town 7700, South Africa.
  • Shipton C; McDonald Institute for Archaeological Research, Cambridge CB2 3ER, UK; British Institute in Eastern Africa, Nairobi 30710, Kenya.
  • Thomas MG; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
  • Tibesasa R; Department of Anthropology and Archaeology, University of Pretoria, Pretoria 0083, South Africa.
  • Welling M; African Studies Centre Leiden, Leiden University, Leiden 2300 RB, Netherlands; African Heritage Ltd, Zomba, Malawi.
  • Hayes VM; Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; Central Clinical School, University of Sydney, Camperdown, NSW 2050, Australia; School of Health Systems and Public Health, University of Pretoria, Gezina 0031, South Africa.
  • Kennett DJ; Department of Anthropology and Institutes for Energy and the Environment, Pennsylvania State University, University Park, PA 16802, USA.
  • Ramesar R; Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
  • Meyer M; Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
  • Pääbo S; Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
  • Patterson N; Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA 02138, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Morris AG; Department of Archaeology, University of Cape Town, Cape Town 7700, South Africa.
  • Boivin N; Max Planck Institute for the Science of Human History, Jena 07745, Germany.
  • Pinhasi R; School of Archaeology and Earth Institute, University College Dublin, Dublin 4, Ireland; Department of Anthropology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
  • Krause J; Max Planck Institute for the Science of Human History, Jena 07745, Germany; Institute for Archeological Sciences, Eberhard-Karls-University, Tuebingen 72070, Germany.
  • Reich D; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: reich@genetics.med.harvard.edu.
Cell ; 171(1): 59-71.e21, 2017 Sep 21.
Article em En | MEDLINE | ID: mdl-28938123
ABSTRACT
We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers ∼8,100-2,500 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers ∼1,400 years ago. We document how the spread of farmers from western Africa involved complete replacement of local hunter-gatherers in some regions, and we track the spread of herders by showing that the population of a ∼3,100-year-old pastoralist from Tanzania contributed ancestry to people from northeastern to southern Africa, including a ∼1,200-year-old southern African pastoralist. The deepest diversifications of African lineages were complex, involving either repeated gene flow among geographically disparate groups or a lineage more deeply diverging than that of the San contributing more to some western African populations than to others. We finally leverage ancient genomes to document episodes of natural selection in southern African populations. PAPERCLIP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / População Negra Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / População Negra Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article