Assessing risk for Mendelian disorders in a Bronx population.
Mol Genet Genomic Med
; 5(5): 516-523, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28944235
ABSTRACT
BACKGROUND:
To identify variants likely responsible for Mendelian disorders among the three major ethnic groups in the Bronx that might be useful to include in genetic screening panels or whole exome sequencing filters and to estimate their likely prevalence in these populations.METHODS:
Variants from a high-density oligonucleotide screen of 192 members from each of the three ethnic-national populations (African Americans, Puerto Ricans, and Dominicans) were evaluated for overlap with next generation sequencing data. Variants were curated manually for clinical validity and utility using the American College of Medical Genetics (ACMG) scoring system. Additional variants were identified through literature review.RESULTS:
A panel of 75 variants displaying autosomal dominant, autosomal recessive, autosomal recessive/digenic recessive, X-linked recessive, and X-linked dominant inheritance patterns representing 39 Mendelian disorders were identified among these populations.CONCLUSION:
Screening for a broader range of disorders could offer the benefits of early or presymptomatic diagnosis and reproductive choice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Mol Genet Genomic Med
Ano de publicação:
2017
Tipo de documento:
Article